USMLE Step 2 CK Renal and Reproductive Practice Questions
7–13% of Step 2 CK · 37 practice questions with a note on every option
316 questions in 16 timed 30-minute blocks, with your score in renal and reproductive and every other content area.
Free renal and reproductive drillA 54-year-old woman has screening mammography that shows a new 9-mm irregular, spiculated mass in the left breast. Diagnostic mammography and targeted ultrasonography confirm a solid hypoechoic mass with indistinct margins, and the radiologist classifies it as BI-RADS category 4C. She has no palpable mass, nipple discharge, or skin changes. Which of the following is the most appropriate next step?
Renal & Urinary System & Reproductive Systems on Step 2 CK
Renal & Urinary System & Reproductive Systems is 7–13% of Step 2 CK. It combines nephrology and urology with gynecology, so one block can move from hyperkalemia to postmenopausal bleeding.
- Share of Step 2 CK
- 7–13% of the exam, per the USMLE content outline
- On our mock exam
- 31 of 316 questions, with your score for this system in the result
- Our drill
- 10 questions from 37 renal and reproductive questions, untimed, a note on every option; one free attempt, unlimited with a pass

What Step 2 CK renal and reproductive questions test
- Acute kidney injury, chronic kidney disease and electrolyte emergencies
- Urinary tract infection, kidney stones, BPH and urologic cancer
- Testicular torsion and other scrotal emergencies
- Abnormal uterine bleeding, amenorrhea, polycystic ovary syndrome and infertility
- Contraception, menopause, sexually transmitted infections and pelvic inflammatory disease
- Cervical, ovarian and endometrial cancer, and breast disease
Sit all 316 questions in timed blocks
316 questions in 16 timed 30-minute blocks, with your score in renal and reproductive and every other content area.
Free renal and reproductive drillHow to study it
- Learn the next step for each electrolyte emergency, in order.
- Follow current cervical cancer screening by age and test.
- For gynecology, decide first whether the patient could be pregnant.
Common questions
Is obstetrics part of this category?
No. Pregnancy, childbirth and the puerperium is its own Step 2 CK category at 3–7%. This category covers gynecology, breast and the urinary tract.
Which guidelines do these questions follow?
Current US guidance, such as USPSTF screening recommendations, ACOG guidance, the CDC STI Treatment Guidelines and KDIGO for kidney disease. Each explanation names its source.
316 questions in 16 timed 30-minute blocks, with your score in renal and reproductive and every other content area.
Free renal and reproductive drillThe other Step 2 CK systems
Sources
- USMLE: Step 1 (blocks, items, testing day, break time)
- USMLE: Step 2 CK (blocks, items, testing day, break time)
- USMLE: Test delivery software updates for Step 2 CK and Step 1 (May 2026)
- USMLE: Step 1 content outline and specifications
- USMLE: Step 2 CK content outline and specifications
- USMLE: Examination results and scoring (minimum passing scores)
- USMLE Bulletin: Scoring and score reporting (about 60% correct to pass; result timing)
- USMLE Bulletin: Eligibility (attempt limits)
- USMLE: Apply for exams (2026 and 2027 fees, FSMB registration, region fees)
- USMLE: Performance data (pass rates)
- Intealth ECFMG: Fees overview (ECFMG Certification)
Original practice questions written to the USMLE content outlines and current standard references. USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and NBME. Independent practice, not affiliated with or endorsed by the FSMB, NBME or Intealth (ECFMG). Follow current guidelines in clinical practice.