USMLE Step 2 CK Nervous System Practice Questions
5–10% of Step 2 CK · 30 practice questions with a note on every option
316 questions in 16 timed 30-minute blocks, with your score in nervous system and every other content area.
Free nervous system drillA 66-year-old man is brought to the emergency department 90 minutes after his wife found him with sudden weakness of his right arm and leg and difficulty speaking; he had been normal 15 minutes earlier. He takes amlodipine for hypertension. Blood pressure is 172/96 mm Hg, pulse is 84/min and regular, and fingerstick glucose is 132 mg/dL. He has expressive aphasia and right hemiparesis; the NIH Stroke Scale score is 10. Noncontrast CT of the head shows no hemorrhage or established infarct, and CT angiography shows no large-vessel occlusion. He takes no anticoagulants and has had no recent surgery or bleeding. Platelet count and INR are normal. Which of the following is the most appropriate next step in management?
Nervous System & Special Senses on Step 2 CK
Nervous System & Special Senses is 5–10% of Step 2 CK. Time-critical decisions dominate: acute stroke, status epilepticus, head injury and spinal cord compression, with eye and ENT emergencies in the same category.
- Share of Step 2 CK
- 5–10% of the exam, per the USMLE content outline
- On our mock exam
- 24 of 316 questions, with your score for this system in the result
- Our drill
- 10 questions from 30 nervous system questions, untimed, a note on every option; one free attempt, unlimited with a pass

What Step 2 CK nervous system questions test
- Acute stroke: imaging first, thrombolysis and thrombectomy windows, and secondary prevention
- Seizures and status epilepticus
- Headache red flags: subarachnoid hemorrhage, meningitis and giant cell arteritis
- Head injury, raised intracranial pressure and spinal cord emergencies
- Neuromuscular disease: myasthenia gravis, Guillain-Barré syndrome and ALS
- Eye and ENT emergencies: acute angle-closure glaucoma, retinal artery occlusion and epistaxis
Sit all 316 questions in timed blocks
316 questions in 16 timed 30-minute blocks, with your score in nervous system and every other content area.
Free nervous system drillHow to study it
- Learn the order of steps in acute stroke and status epilepticus.
- Know which headaches need imaging or a lumbar puncture today.
- Separate upper from lower motor neuron findings before you name a disease.
Common questions
Are eye problems tested on Step 2 CK?
Yes. The eye and ear sit in Nervous System & Special Senses (5–10% of Step 2 CK). Questions focus on emergencies that threaten vision.
How many neurology questions are on our mock?
24 of 316, inside the content outline’s 5–10% range.
316 questions in 16 timed 30-minute blocks, with your score in nervous system and every other content area.
Free nervous system drillThe other Step 2 CK systems
Sources
- USMLE: Step 1 (blocks, items, testing day, break time)
- USMLE: Step 2 CK (blocks, items, testing day, break time)
- USMLE: Test delivery software updates for Step 2 CK and Step 1 (May 2026)
- USMLE: Step 1 content outline and specifications
- USMLE: Step 2 CK content outline and specifications
- USMLE: Examination results and scoring (minimum passing scores)
- USMLE Bulletin: Scoring and score reporting (about 60% correct to pass; result timing)
- USMLE Bulletin: Eligibility (attempt limits)
- USMLE: Apply for exams (2026 and 2027 fees, FSMB registration, region fees)
- USMLE: Performance data (pass rates)
- Intealth ECFMG: Fees overview (ECFMG Certification)
Original practice questions written to the USMLE content outlines and current standard references. USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and NBME. Independent practice, not affiliated with or endorsed by the FSMB, NBME or Intealth (ECFMG). Follow current guidelines in clinical practice.