USMLE Step 2 CK Blood and Immune Practice Questions
5–10% of Step 2 CK · 28 practice questions with a note on every option
316 questions in 16 timed 30-minute blocks, with your score in blood and immune and every other content area.
Free blood and immune drillA 38-year-old woman is brought to the emergency department because of 1 day of headache and confusion. Temperature is 38.0°C (100.4°F). She has scattered petechiae. Hemoglobin is 7.9 g/dL, platelet count is 11,000/mm³, and the smear shows numerous schistocytes. Lactate dehydrogenase is 1,450 U/L (normal 100-250 U/L), indirect bilirubin is 2.6 mg/dL, and creatinine is 1.4 mg/dL. PT, aPTT, and fibrinogen are normal, and the direct antiglobulin test is negative. Which of the following is the most likely diagnosis?
Blood & Lymphoreticular/Immune Systems on Step 2 CK
Blood & Lymphoreticular/Immune Systems is 5–10% of Step 2 CK. Expect anemia workups, anticoagulation decisions, transfusion reactions and the infections and cancers that affect blood and immunity.
- Share of Step 2 CK
- 5–10% of the exam, per the USMLE content outline
- On our mock exam
- 23 of 316 questions, with your score for this system in the result
- Our drill
- 10 questions from 28 blood and immune questions, untimed, a note on every option; one free attempt, unlimited with a pass
What Step 2 CK blood and immune questions test
- Anemia workup and treatment
- Bleeding and clotting disorders, and anticoagulant reversal
- Diagnosis and treatment of deep vein thrombosis and pulmonary embolism
- Transfusion reactions and transfusion thresholds
- Leukemia, lymphoma and myeloma, and neutropenic fever
- HIV care, anaphylaxis and immunodeficiency
Sit all 316 questions in timed blocks
316 questions in 16 timed 30-minute blocks, with your score in blood and immune and every other content area.
Free blood and immune drillHow to study it
- Learn the next test for each anemia pattern.
- Learn how to reverse each anticoagulant in a bleeding patient.
- Treat neutropenic fever as an emergency: learn the first antibiotics and when to start them.
Common questions
Is HIV in this category?
In our bank, HIV care (testing, starting treatment, opportunistic infection prophylaxis) sits in Blood & Lymphoreticular/Immune Systems, as the immune system category of the content outline.
How many questions on our mock?
23 of 316, inside the content outline’s 5–10% range.
316 questions in 16 timed 30-minute blocks, with your score in blood and immune and every other content area.
Free blood and immune drillThe other Step 2 CK systems
Sources
- USMLE: Step 1 (blocks, items, testing day, break time)
- USMLE: Step 2 CK (blocks, items, testing day, break time)
- USMLE: Test delivery software updates for Step 2 CK and Step 1 (May 2026)
- USMLE: Step 1 content outline and specifications
- USMLE: Step 2 CK content outline and specifications
- USMLE: Examination results and scoring (minimum passing scores)
- USMLE Bulletin: Scoring and score reporting (about 60% correct to pass; result timing)
- USMLE Bulletin: Eligibility (attempt limits)
- USMLE: Apply for exams (2026 and 2027 fees, FSMB registration, region fees)
- USMLE: Performance data (pass rates)
- Intealth ECFMG: Fees overview (ECFMG Certification)
Original practice questions written to the USMLE content outlines and current standard references. USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and NBME. Independent practice, not affiliated with or endorsed by the FSMB, NBME or Intealth (ECFMG). Follow current guidelines in clinical practice.