USMLE Step 2 CK Endocrine Practice Questions
3–7% of Step 2 CK · 20 practice questions with a note on every option
316 questions in 16 timed 30-minute blocks, with your score in endocrine and every other content area.
Free endocrine drillA 67-year-old woman comes for a health maintenance visit. She has never had a fracture and takes no medications. She has never had bone density testing. She does not smoke and drinks one glass of wine weekly. Her mother had a hip fracture at age 82. BMI is 24 kg/m². Examination shows no kyphosis or height loss. Which of the following is the most appropriate screening test?
Endocrine System on Step 2 CK
The Endocrine System is 3–7% of Step 2 CK. Diabetes leads, from diagnosis and drug choice to diabetic ketoacidosis, with thyroid, adrenal, pituitary and calcium disorders around it.
- Share of Step 2 CK
- 3–7% of the exam, per the USMLE content outline
- On our mock exam
- 16 of 316 questions, with your score for this system in the result
- Our drill
- 10 questions from 20 endocrine questions, untimed, a note on every option; one free attempt, unlimited with a pass
What Step 2 CK endocrine questions test
- Diabetes: diagnosis, drug choice by comorbidity, insulin and hypoglycemia
- Diabetic ketoacidosis and the hyperosmolar hyperglycemic state
- Thyroid disease, thyroid nodules and thyroid storm
- Adrenal insufficiency, Cushing syndrome and pheochromocytoma
- Hypercalcemia, hyponatremia from endocrine causes and pituitary disease
- Osteoporosis screening and treatment
Sit all 316 questions in timed blocks
316 questions in 16 timed 30-minute blocks, with your score in endocrine and every other content area.
Free endocrine drillHow to study it
- Learn the ADA approach to choosing a second drug by heart, kidney and weight goals.
- Learn the order of treatment in diabetic ketoacidosis, including potassium.
- Work up every thyroid nodule with TSH first, then ultrasound.
Common questions
Which diabetes guideline do the questions follow?
The American Diabetes Association Standards of Care in Diabetes—2026.
How many endocrine questions are on our mock?
16 of 316, inside the content outline’s 3–7% range.
316 questions in 16 timed 30-minute blocks, with your score in endocrine and every other content area.
Free endocrine drillThe other Step 2 CK systems
Sources
- USMLE: Step 1 (blocks, items, testing day, break time)
- USMLE: Step 2 CK (blocks, items, testing day, break time)
- USMLE: Test delivery software updates for Step 2 CK and Step 1 (May 2026)
- USMLE: Step 1 content outline and specifications
- USMLE: Step 2 CK content outline and specifications
- USMLE: Examination results and scoring (minimum passing scores)
- USMLE Bulletin: Scoring and score reporting (about 60% correct to pass; result timing)
- USMLE Bulletin: Eligibility (attempt limits)
- USMLE: Apply for exams (2026 and 2027 fees, FSMB registration, region fees)
- USMLE: Performance data (pass rates)
- Intealth ECFMG: Fees overview (ECFMG Certification)
Original practice questions written to the USMLE content outlines and current standard references. USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and NBME. Independent practice, not affiliated with or endorsed by the FSMB, NBME or Intealth (ECFMG). Follow current guidelines in clinical practice.