NPTE Other Systems and System Interactions Practice Questions
5 areas of FSBPT’s content outline · 21–34 of the 180 scored questions
225 questions across the whole content outline in 5 hours, with a score for Other Systems so you know where you stand.
Free Other Systems drillHow is biofeedback used in pelvic floor rehabilitation?
Other Systems and System Interactions on the NPTE-PT
This page groups five outline areas that together carry 21–34 of the 180 scored questions: metabolic and endocrine (4–6), gastrointestinal (3–6), genitourinary (2–5), lymphatic (4–7) and system interactions (8–10). Many questions are screening questions: deciding when pain or a symptom comes from an organ rather than the musculoskeletal system, and when to refer.
- Share of the exam
- Metabolic & Endocrine Systems 4–6, Gastrointestinal System 3–6, Genitourinary System 2–5, Lymphatic System 4–7, System Interactions 8–10 of the 180 scored questions (FSBPT outline, effective January 2024)
- On our mock exam
- 26 scored questions, inside FSBPT’s range
- Our drill
- 10 questions from 86 other systems questions, untimed, an explanation after every answer; one free attempt, unlimited with a pass

What Other Systems and System Interactions questions test
- Metabolic and endocrine: diabetes and exercise, hypoglycemia and ketones, A1c, thyroid disorders, Cushing syndrome, obesity, osteoporosis and kidney disease
- Gastrointestinal and genitourinary: referred pain patterns, Murphy, Rovsing and psoas signs, GI bleeding, hernia, reflux, bowel programs, incontinence types, pelvic floor training and biofeedback
- Lymphatic: lymphedema stages, the Stemmer sign, lipedema, complete decongestive therapy, compression and exercise after breast cancer
- System interactions: cancer and chemotherapy, lab values that limit activity, pregnancy, autoimmune disease, HIV, sickle cell disease, polypharmacy, depression and suicide risk, and dimensions of pain
Sit the full exam under the real clock
225 questions across the whole content outline in 5 hours, with a score for Other Systems so you know where you stand.
Free Other Systems drillHow to study it
- Learn the visceral referral map: gallbladder to the right shoulder, pancreas to the midback, kidney to the flank and groin, duodenum to the thoracic spine.
- Know the lab values that hold or limit therapy: platelets, neutrophils, INR, hemoglobin, potassium and glucose.
- For system interactions questions, ask which condition limits the session most today; the answer usually protects against the most serious risk.
- Take the other systems drill until you score 80% or better.
Common questions
Is pelvic floor on the NPTE-PT?
Yes, within the genitourinary system (2–5 scored questions). The outline names bladder programs, biofeedback and pelvic floor retraining as interventions.
What does system interactions mean on the NPTE?
Conditions whose main impact is on more than one system, such as cancer, multitrauma, sarcoidosis, autoimmune disorders or pregnancy, plus comorbidities, polypharmacy, psychological conditions and pain. The outline gives it 8–10 of the 180 scored questions.
225 questions across the whole content outline in 5 hours, with a score for Other Systems so you know where you stand.
Free Other Systems drillThe other NPTE-PT content areas
- Cardiovascular and Pulmonary Systems
- Musculoskeletal System
- Neuromuscular and Nervous Systems
- Integumentary System
- Equipment, Devices and Technologies
- Therapeutic Modalities
- Safety and Protection
- Professional Responsibilities and Research
- Special tests drill
- Lab values and vital signs drill
- NPTE-PT practice exam (225 questions, 5 hours)
Sources
- FSBPT: NPTE Candidate Handbook (version 2025.02): format, timing, scoring, fees, testing limits, results
- FSBPT: NPTE-PT Test Content Outline, effective January 2024
- FSBPT: NPTE Content (outlines in effect since January 2024)
- FSBPT: Future test dates (2027 PT dates)
- FSBPT: Retake Exam
- FSBPT: Practice Exam and Assessment Tool (PEAT)
Original practice questions for exam preparation, written to the NPTE-PT Test Content Outline (effective January 2024). They are not NPTE questions or recalled questions. Independent practice, not affiliated with or endorsed by the Federation of State Boards of Physical Therapy (FSBPT) or Prometric. NPTE is a registered trademark of FSBPT.