USMLE Step 1 Reproductive and Endocrine Practice Questions
12–16% of Step 1 · 45 practice questions with a note on every option
280 questions in 14 timed 30-minute blocks, with your score in reproductive and endocrine and every other content area.
Free reproductive and endocrine drillA 38-year-old woman comes to the physician because of 1 week of anterior neck pain radiating to both ears, palpitations, and fatigue. Two weeks earlier she had a sore throat and rhinorrhea. Her temperature is 38.0°C (100.4°F) and pulse is 104/min. The thyroid gland is firm and exquisitely tender to palpation, without discrete nodules. Erythrocyte sedimentation rate is 78 mm/h. Serum TSH is 0.05 μU/mL and free thyroxine (T4) is 2.6 ng/dL. Which of the following is the most likely finding on further evaluation?
Reproductive & Endocrine Systems on Step 1
Reproductive & Endocrine Systems is 12–16% of Step 1, the largest single category. It links hormones to their feedback loops: a question gives you lab values and symptoms and asks where the axis is broken.
- Share of Step 1
- 12–16% of the exam, per the USMLE content outline
- On our mock exam
- 38 of 280 questions, with your score for this system in the result
- Our drill
- 10 questions from 45 reproductive and endocrine questions, untimed, a note on every option; one free attempt, unlimited with a pass
What Step 1 reproductive and endocrine questions test
- The hypothalamic-pituitary axis, pituitary tumors and disorders of ADH
- Thyroid, adrenal and parathyroid disease, with the lab pattern of each
- Diabetes mellitus, insulin and the drugs that lower glucose
- Sexual development and its disorders, puberty and the menstrual cycle
- Pregnancy physiology, and gynecologic, breast, testicular and prostate pathology
- Reproductive pharmacology: hormonal contraception, androgens and antiandrogens, and drugs for infertility
Sit all 280 questions in timed blocks
280 questions in 14 timed 30-minute blocks, with your score in reproductive and endocrine and every other content area.
Free reproductive and endocrine drillHow to study it
- Draw each hormonal axis with its feedback and predict the labs for a primary versus a secondary disorder.
- Learn the MEN syndromes and their genes as one table.
- Learn diabetes drugs by mechanism and the one adverse effect each is known for.
Common questions
Why is this the largest Step 1 category?
The content outline groups reproductive and endocrine systems together at 12–16% of Step 1. Our 280-question mock includes 38 questions from this category.
Do these questions include lab values?
Often. Expect hormone levels in the stem. Our test interface has a lab values panel with standard reference ranges, as the real exam does.
280 questions in 14 timed 30-minute blocks, with your score in reproductive and endocrine and every other content area.
Free reproductive and endocrine drillThe other Step 1 systems
Sources
- USMLE: Step 1 (blocks, items, testing day, break time)
- USMLE: Step 2 CK (blocks, items, testing day, break time)
- USMLE: Test delivery software updates for Step 2 CK and Step 1 (May 2026)
- USMLE: Step 1 content outline and specifications
- USMLE: Step 2 CK content outline and specifications
- USMLE: Examination results and scoring (minimum passing scores)
- USMLE Bulletin: Scoring and score reporting (about 60% correct to pass; result timing)
- USMLE Bulletin: Eligibility (attempt limits)
- USMLE: Apply for exams (2026 and 2027 fees, FSMB registration, region fees)
- USMLE: Performance data (pass rates)
- Intealth ECFMG: Fees overview (ECFMG Certification)
Original practice questions written to the USMLE content outlines and current standard references. USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and NBME. Independent practice, not affiliated with or endorsed by the FSMB, NBME or Intealth (ECFMG). Follow current guidelines in clinical practice.