NAPLEX Patient Assessment and Treatment Planning Practice Questions
Domain 3 of the 2025 NAPLEX content outline, about 80 of the 200 scored questions (40%). The largest domain: medication and allergy histories, appropriateness of therapy, interactions, dosing errors, adverse reactions, toxicology, adherence, monitoring plans, patient education, OTC products and supplements, and devices.
225 questions in 6 hours across all five content domains, with an explanation for every answer and a score by domain.
Or try the free assessment and treatment planning drillA patient with type 2 diabetes admits that she skips insulin doses near the end of each month because she cannot afford her copay. What is the pharmacist's most appropriate first action?
What Domain 3 covers
- Medication history, allergy history and reconciliation
- Health histories, screenings and assessments
- Patient conditions and special populations: pathophysiology, appropriateness of therapy, interactions, errors and omissions, adverse drug reactions, toxicologic exposures and overdoses, adherence
- Therapeutic monitoring and plan changes: goals, safety, effectiveness
- Patient education: lifestyle, medication use and storage, disease management
- Over-the-counter medications and dietary supplements
- Devices and self-monitoring tests
Our full practice exam gives this domain 91 of its 225 questions, the outline’s share, and scores it separately.

Then sit all 225 questions under the clock
225 questions in 6 hours across all five content domains, with an explanation for every answer and a score by domain.
Or try the free assessment and treatment planning drillCommon questions
How much of the NAPLEX is assessment and treatment planning?
Person-Centered Assessment and Treatment Planning is Domain 3 of the content outline effective May 1, 2025, 40% of the scored questions, about 80 of 200.
More NAPLEX guides
Source: NABP, NAPLEX Content Outline (effective May 1, 2025). Original independent practice; NAPLEX is a registered trademark of NABP. Not affiliated with or endorsed by NABP.