NAPLEX Foundational Knowledge Practice Questions
Domain 1 of the 2025 NAPLEX content outline, about 50 of the 200 scored questions (25%). Pharmacology, pharmacokinetics and pharmacogenomics, pharmaceutics, nonsterile and sterile compounding, every kind of pharmacy calculation, drug development, research design and biostatistics, and drug-information resources.
225 questions in 6 hours across all five content domains, with an explanation for every answer and a score by domain.
Or try the free foundational knowledge drillHow does an enteric coating delay drug release until the tablet leaves the stomach?
What Domain 1 covers
- Pharmaceutical science: pharmacology; pharmacokinetics, pharmacodynamics and pharmacogenomics; pharmaceutics
- Pharmaceutical compounding: nonsterile and sterile preparations
- Pharmaceutical calculations: patient parameters, dispensed quantities, rates, dose conversions, concentrations and osmolarity, compounding quantities, nutrition, biostatistics and pharmacokinetic parameters
- Drug development processes (clinical trial phases, emergency use authorizations)
- Research design and biostatistics (blinding, randomization, bias, statistical tests, ethics)
- Retrieval and interpretation of primary, secondary and tertiary resources
Our full practice exam gives this domain 56 of its 225 questions, the outline’s share, and scores it separately.
Then sit all 225 questions under the clock
225 questions in 6 hours across all five content domains, with an explanation for every answer and a score by domain.
Or try the free foundational knowledge drillCommon questions
How much of the NAPLEX is foundational knowledge?
Foundational Knowledge for Pharmacy Practice is Domain 1 of the content outline effective May 1, 2025, 25% of the scored questions, about 50 of 200.
More NAPLEX guides
Source: NABP, NAPLEX Content Outline (effective May 1, 2025). Original independent practice; NAPLEX is a registered trademark of NABP. Not affiliated with or endorsed by NABP.