USMLE Step 1 blood and immune practice questions

10 questions · Untimed · Explanation after each question

Anemias, hemoglobinopathies, hemostasis and thrombosis, leukemia, lymphoma and myeloma, immunodeficiency, hypersensitivity, transplant immunology and the drugs that act on blood. 9–13% of Step 1.

Line drawing of a microscope beside a rack of blood tubes, a blood smear slide and a bag of blood on a drip stand

Before you start

Every question is a clinical vignette with five options and one best answer. Step 1 questions ask for the mechanism, cause or finding behind the case. After each answer you see why the key is best, a note on every option and the reference behind it. A lab values panel is one click away, as on test day.
Check each answer to see the explanation before moving on. Checked answers cannot be changed.

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Create a free account to start. Every drill includes one free attempt. A USMLE pass unlocks the full-length Step 1 and Step 2 CK mock exams and unlimited drills in every content area.

Original practice questions written to the USMLE content outlines and current standard references. USMLE® is a joint program of the Federation of State Medical Boards (FSMB) and NBME. Independent practice, not affiliated with or endorsed by the FSMB, NBME or Intealth (ECFMG).